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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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Related Experiment Video

Updated: May 18, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Wnt signaling regulates postembryonic hypothalamic progenitor differentiation.

Xu Wang1, Daniel Kopinke, Junji Lin

  • 1Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84112, USA.

Developmental Cell
|September 15, 2012
PubMed
Summary
This summary is machine-generated.

Wnt signaling controls neural progenitor cells in the zebrafish hypothalamus. It drives proliferation early on and later regulates differentiation, inhibiting radial glia development in both young and adult stages.

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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Related Experiment Videos

Last Updated: May 18, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Wnt signaling is implicated in neural progenitor maintenance and neuronal differentiation.
  • The specific roles of Wnt/β-catenin activity in the hypothalamus, particularly postembryonically, remain incompletely understood.

Purpose of the Study:

  • To investigate the role of Wnt/β-catenin signaling in zebrafish hypothalamic neurogenesis.
  • To elucidate the temporal requirements of Wnt activity in neural progenitor proliferation and differentiation.

Main Methods:

  • Utilized zebrafish as a model organism to study hypothalamic development.
  • Manipulated Wnt/β-catenin signaling pathways at different developmental stages.
  • Examined neural progenitor proliferation and differentiation, including radial glia development.
  • Compared findings with adult mouse hypothalamic progenitor Wnt activity.

Main Results:

  • Wnt/β-catenin activity is essential for early embryonic proliferation of unspecified hypothalamic progenitors.
  • Sequential activation and inhibition of Wnt signaling are required for later neural progenitor differentiation.
  • Wnt activity negatively regulates radial glia differentiation in both embryonic and adult stages.
  • Conserved role of Wnt activity in inhibiting radial glia differentiation in adult mouse hypothalamus.

Conclusions:

  • The vertebrate hypothalamus serves as a model for studying Wnt-regulated postembryonic neural progenitor differentiation.
  • Wnt signaling plays distinct roles in hypothalamic neurogenesis, governing both progenitor proliferation and differentiation.
  • Temporal control of Wnt activity is critical for proper hypothalamic development and neurogenesis.