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A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe
Published on: June 12, 2012
Eye preservation tectonic graft using glycerol-preserved donor cornea
1Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. hclinn@adm.cgmh.org.tw
Eye (London, England)
|September 15, 2012
Summary
Tectonic grafts using glycerol-preserved donor corneas effectively treated perforated keratitis, avoiding evisceration in most cases. This approach offers a viable alternative for managing severe corneal perforations.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Tissue Banking
Background:
- Perforated keratitis presents a significant challenge, often necessitating globe-sparing procedures.
- Glycerol-preserved donor corneas offer a readily available option for corneal transplantation.
Purpose of the Study:
- To evaluate the surgical outcomes of tectonic grafts using glycerol-preserved donor corneas in patients with perforated keratitis.
- To assess the efficacy of this technique in preserving ocular integrity and avoiding evisceration.
Main Methods:
- Retrospective review of 14 patients with perforated keratitis treated with glycerol-preserved corneal grafts between 2004 and 2010.
- Analysis of clinical features, causative agents, adjuvant therapies, and surgical outcomes, including re-epithelialization and globe integrity.
Main Results:
- Satisfactory anatomical integrity was achieved in 57.14% of grafts; 48.85% required conjunctival flaps for delayed re-epithelialization.
- Thirteen of fourteen patients avoided evisceration or exenteration, with one requiring evisceration due to intractable glaucoma.
- Common etiologies included bacterial and fungal keratitis.
Conclusions:
- Tectonic grafting with glycerol-preserved donor corneas, potentially combined with anterior vitrectomy and conjunctival flaps, is an effective strategy for perforated keratitis.
- This method serves as a valuable alternative to evisceration, preserving ocular structure and function.
