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Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
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CMOS image sensor-based immunodetection by refractive-index change.

Jasmine P Devadhasan1, Sanghyo Kim

  • 1Department of Bionanotechnology, Gachon University, Gyeonggi-Do, Republic of Korea.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|September 15, 2012
PubMed
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This study reveals a novel biosensor using complementary metal oxide semiconductor (CMOS) image sensors for detecting cardiovascular disease markers. The sensor achieves high sensitivity for antigen-antibody interactions on indium nanoparticle substrates, enabling point-of-care diagnostics.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Biosensing

Background:

  • Complementary metal oxide semiconductor (CMOS) image sensors offer potential for novel biosensor development.
  • The nanoscale detection mechanism of antigen-antibody (Ag-Ab) interactions using CMOS image sensors requires further elucidation.
  • Advancing point-of-care diagnostic devices necessitates a deeper understanding of these biosensing mechanisms.

Purpose of the Study:

  • To investigate the mechanism of CMOS image sensor-based detection of cardiovascular disease markers.
  • To analyze antigen-antibody (Ag-Ab) interactions on indium nanoparticle (InNP) substrates.
  • To establish a sensitive and feasible method for point-of-care diagnostics.

Main Methods:

  • Utilized a CMOS image sensor for analyzing cardiovascular disease markers, specifically C-reactive protein (CRP) and troponin I.

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  • Employed indium nanoparticle (InNP) substrates to facilitate antigen-antibody (Ag-Ab) interactions.
  • Measured detection sensitivity via simple photon count variation under ambient room light conditions.

    • Main Results:

    • Successfully demonstrated CMOS image sensor-based detection of CRP and troponin I Ag-Ab interactions.
    • Achieved high sensitivity, detecting proteins at concentrations as low as fg/mL.
    • Observed a significant change in refractive index upon protein adsorption on the InNP substrate, identified as a key factor.

    Conclusions:

    • A CMOS image sensor-based immunoassay utilizing InNP substrates is a viable technology for detecting cardiovascular disease biomarkers.
    • The predominant mechanism involves significant refractive index changes due to protein adsorption.
    • This approach holds promise for the development of accessible, point-of-care diagnostic tools.