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CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells
Published on: October 18, 2014
Single-cell gel electrophoresis (Comet) assay in nano-genotoxicology
Maricica Pacurari1, Vincent Castranova
1Mary Babb Cancer Center, School of Medicine, West Virginia University, Morgantown, WV, USA.
Methods in Molecular Biology (Clifton, N.J.)
|September 15, 2012
Abstract:
The Comet assay, or single-cell gel electrophoresis assay, is an easy and simple yet reliable method to evaluate DNA damage in cells. Under the alkaline conditions of this method, DNA strand breaks and alkaline-labile sites are detected. Here we describe the alkaline version of the Comet assay with applications in testing nanoparticles.
