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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

GSK3β and cyclin D1 expression predicts outcome in early breast cancer patients

Mary Anne Quintayo1, Alison F Munro, Jeremy Thomas

  • 1Endocrine Cancer Group, Edinburgh University, Edinburgh, UK.

Breast Cancer Research and Treatment
|September 15, 2012
PubMed

Insights

High GSK3β expression indicates poor breast cancer survival, while cyclin D1 overexpression suggests a good prognosis. Analyzing both may predict outcomes in early breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Glycogen synthase kinase 3β (GSK3β) is inactivated by the PI3K/Akt pathway, affecting cell cycle regulators like cyclin D1.
  • The CCND1 gene, encoding cyclin D1, is frequently amplified in breast cancer, where cyclin D1 is often overexpressed.

Purpose of the Study:

  • To investigate the prognostic significance of GSK3β and cyclin D1 expression and CCND1 gene amplification in early breast cancer.
  • To determine the association of these markers with distant relapse-free survival (DRFS) and breast cancer-specific survival.

Main Methods:

  • Protein expression of GSK3β, phosphorylated-GSK3β (p-GSK3β), and cyclin D1 was analyzed.
  • CCND1 gene expression was examined using tissue microarrays from 1,686 early breast cancer patients.
  • Statistical analysis, including multivariate analysis, was performed to assess survival outcomes.

Main Results:

  • High GSK3β expression correlated with reduced DRFS.
  • No significant association was found between p-GSK3β and breast cancer-specific survival.
  • CCND1 amplification was linked to poor DRFS, whereas cyclin D1 overexpression was associated with increased DRFS.

Conclusions:

  • GSK3β and cyclin D1 expression levels may serve as valuable prognostic markers in early breast cancer.
  • Combined analysis of GSK3β and cyclin D1 offers potential for improved prognostic assessment.
  • Understanding the interplay between GSK3β, cyclin D1, and breast cancer progression is crucial for therapeutic strategies.

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