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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...

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Related Experiment Video

Updated: May 18, 2026

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using &#967;CRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

Long non-coding RNAs coordinate cellular responses to stress.

Subhash C Lakhotia1

  • 1Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India. lakhotia@bhu.ac.in

Wiley Interdisciplinary Reviews. RNA
|September 15, 2012
PubMed
Summary

Stress-inducible long non-coding RNAs (lncRNAs) coordinate cellular responses by binding proteins. These adaptable ncRNAs act as hubs, integrating cellular networks to maintain homeostasis or trigger cell death.

Related Experiment Videos

Last Updated: May 18, 2026

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using &#967;CRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

Area of Science:

  • Molecular Biology
  • Genetics
  • Cellular Biology

Background:

  • The heat shock RNA omega (hsrω) gene was the first identified non-coding RNA (ncRNA) inducible by cell stress.
  • Subsequent research has identified numerous stress-inducible long non-coding RNAs (lncRNAs) across various organisms.
  • Knowledge of the stress transcriptome is fragmented due to rapid sequence divergence in lncRNAs.

Purpose of the Study:

  • To review the known functions and mechanisms of stress-inducible lncRNAs.
  • To highlight the emerging theme of lncRNAs as integrative hubs in cellular stress response networks.
  • To discuss the evolutionary adaptability of lncRNAs in response to environmental changes.

Main Methods:

  • Literature review and synthesis of existing research on stress-inducible lncRNAs.
  • Analysis of lncRNA structure-function relationships and protein-binding motifs.
  • Exploration of lncRNA roles in cellular homeostasis and stress adaptation.

Main Results:

  • Stress-related lncRNAs are often localized to nuclear domains or the nucleolus, sequestering RNA-processing proteins.
  • lncRNAs modulate protein activity or sequester proteins, impacting transcriptional and translational regulation.
  • A common mechanism involves lncRNAs targeting key proteins in stress response pathways, exerting widespread effects.

Conclusions:

  • Stress-inducible lncRNAs act as crucial hubs, coordinating cellular networks for survival or cell death.
  • The sequence variability and motif-based protein interactions of lncRNAs facilitate adaptability to environmental stress.
  • lncRNAs play a vital role in integrating cellular responses to maintain homeostasis under stress conditions.