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Updated: May 18, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
The epidemiology of pediatric bone and joint infections in Cambodia, 2007-11
Nicole Stoesser1, Joanna Pocock, Catrin E Moore
1Angkor Hospital for Children, Siem Reap, Cambodia. nicole.stoesser@ndm.ox.ac.uk
Insights
Osteoarticular infections are common in Cambodian children, often caused by Staphylococcus aureus. While surgical intervention and sequelae are frequent, methicillin-resistant strains are not a significant issue in this Asian setting.
Area of Science:
- Pediatric Infectious Diseases
- Musculoskeletal Infections
- Global Health
Background:
- Limited data exists on osteoarticular infections in Asian resource-limited settings.
- These infections pose significant challenges in pediatric populations.
Purpose of the Study:
- To describe the epidemiology and clinical characteristics of osteoarticular infections in Cambodian children.
- To identify common pathogens and outcomes in a resource-limited Asian context.
Main Methods:
- Retrospective study of 81 pediatric patients at Angkor Hospital for Children, Cambodia (2007-2011).
- Analysis of infection types, causative agents, treatment duration, surgical interventions, and sequelae.
Main Results:
- Osteoarticular infections occurred at 13.8/100,000 hospital attendances, predominantly osteomyelitis and septic arthritis.
- Staphylococcus aureus was the most common pathogen (36% of cases), with low rates of methicillin-resistance (MRSA).
- High rates of surgical intervention (96%) and sequelae (46%) were observed, with one fatality.
Conclusions:
- Osteoarticular infections are prevalent in this Cambodian setting, characterized by frequent surgical needs and long-term complications.
- Staphylococcus aureus is the primary bacterial cause, with MRSA not being a predominant concern.
- Findings highlight the need for effective management strategies in resource-limited Asian environments.
Abstract:
There are limited data on osteoarticular infections from resource-limited settings in Asia. A retrospective study of patients presenting to the Angkor Hospital for Children, Cambodia, January 2007-July 2011, identified 81 cases (28% monoarticular septic arthritis, 51% single-limb osteomyelitis and 15% multisite infections). The incidence was 13.8/100 000 hospital attendances. The median age was 7.3 years, with a male/female ratio of 1.9:1; 35% presented within 5 days of symptom onset (median 7 days). Staphylococcus aureus was cultured in 29 (36%) cases (52% of culture-positive cases); one isolate was methicillin-resistant (MRSA). Median duration of antimicrobial treatment was 29 days (interquartile range 21-43); rates of surgical intervention were 96%, and 46% of children had sequelae, with one fatality. In this setting osteoarticular infections are relatively common with high rates of surgical intervention and sequelae. Staphylococcus aureus is the commonest culturable cause, but methicillin-resistant S. aureus is not a major problem, unlike in other Asian centers.
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