Related Experiment Video
Updated: May 18, 2026
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
The prevalence of diastolic dysfunction in patients with hypertension referred for echocardiographic assessment of
Abdul Latif Mohamed1, Jun Yong, Jamil Masiyati
1International Medical University, Clinical School, Seremban 70300, Negeri Sembilan, Malaysia.
Insights
Hypertension often leads to diastolic dysfunction, a reversible condition impacting heart health. Early detection in hypertensive patients is crucial for preventing cardiac complications and improving outcomes.
Area of Science:
- Cardiology
- Internal Medicine
- Hypertension Research
Background:
- Hypertension is a primary global cause of congestive cardiac failure.
- Diastolic dysfunction in hypertension is an early, poor prognostic indicator and a reversible condition.
- Optimal hypertension therapy is challenging, necessitating early detection of complications.
Purpose of the Study:
- To assess the prevalence of diastolic dysfunction in hypertensive patients.
- To identify contributing factors to diastolic dysfunction, including patient demographics, hypertension severity, and medication.
- To analyze the relationship between hypertension duration, blood pressure, and diastolic dysfunction.
Main Methods:
- Doppler echocardiography was used to analyze diastolic dysfunction via the E/A ratio.
- Fifty hypertensive patients from Seremban General Hospital were selected for the study.
- Data collected included age, gender, blood pressure, hypertension duration, cardiac history, and medications.
Main Results:
- Diastolic dysfunction was identified in 44% of hypertensive patients (22 out of 50).
- Factors associated with diastolic dysfunction included longer hypertension duration (>8 years), pre-existing ischemic heart disease/acute myocardial infarction, and stages II-III hypertension.
- Prevalence varied by gender (39.1% males, 48.1% females) and was observed in patients on ACE-inhibitors (18%) and beta-blockers (28%).
Conclusions:
- Hypertension duration, systolic and diastolic blood pressure, and patient age are significant indicators for predicting diastolic dysfunction.
- Early identification and management of diastolic dysfunction in hypertensive individuals are vital.
- Further research into the impact of specific antihypertensive drug classes on diastolic dysfunction is warranted.
Abstract:
Hypertension is the major cause of congestive cardiac failure all over the world. It is under diagnosed and achievement of optimal therapy is difficult and costly. Diastolic dysfunction is an early poor prognostic factor in hypertension and is a reversible condition. Early detection and treatment is necessary to avoid cardiac complications. The objective of this study was to assess the occurrence of diastolic dysfunction in hypertensive patients referred for echocardiograph assessment of left ventricular function in a secondary hospital. It was also designed to determine whether contributing factors such as age, gender, systolic and diastolic pressure, duration of hypertension, previous myocardial infarct or ischemic heart disease and choice of anti-hypertensive drugs influence the development of diastolic dysfunction in these hypertensive patients. The analysis of diastolic dysfunction was based on the E/A ratio using Doppler echocardiogram. All of the patients were recruited from the Echocardiography Unit, Department of Medicine, Seremban General Hospital. Fifty patients with history of hypertension were selected for the study. Out of These 22 patients (44%) were found to have diastolic dysfunction; 39.1% of male patients (9 out of 23) and 48.1% of female patients (13 out of 27). Other contributing factors of diastolic dysfunction were found in patients : (a) with more than 8 years history of hypertension (12%) (b) with history of preexisting IHD/AMI (20%), (c) stages II - III of systolic hypertension based on 6th Joint National Committee recommendation (73%) (d) on ACE-inhibitor (18%) and (e) on Beta-blocker (28%) In conclusion, the study had demonstrated that the duration of hypertension, both systolic and diastolic blood pressure and age of patients are important prognostic indicators in predicting the development of diastolic dysfunction in hypertensive patients.
Related Concept Videos
01:29Heart Failure II: Pathophysiology
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:20Mitral Regurgitation I: Introduction
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
01:19Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment: