Related Experiment Videos
Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells
Hitomi Yoshida1, Naoko Okumura, Yuri Nishimura
1Department of Environmental Health Science, Nara Women's University, Nara 630-8506, Japan.
Abstract:
In the present study, we aimed to determine the effects of herbs or spices on the expression of presenilin 1, a molecule involved in γ-secretase activity and the generation of amyloid-β peptide in Alzheimer's disease. Western blot analysis revealed that presenilin 1 protein expression was down-regulated by stimulation with turmeric or cinnamon extracts in vitro, while the effects on presenilin 1 gene expression examined by reverse transcriptase-polymerase chain reaction were unaltered. Our results showed that curcumin, a component of turmeric, induced the down-regulation of presenilin 1 protein in Jurkat and K562 cell lines.
Related Concept Videos
Abnormal Proliferation
The JAK-STAT Signaling Pathway
Inhibition of Cdk Activity
Inhibition of CDK Activity
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...