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Updated: May 18, 2026
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Effects of dexamethasone on the development of neonatal rats and level of active caspase-3 in brain cortex
P N Menshanov1, V V Muzyka, N N Dygalo
1Laboratory of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. eternity@bionet.nsc.ru
Abstract:
Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased expression of the active form of caspase-3 in the cerebral cortex was associated with earlier eye opening and delayed formation of startle-reflex in rats.
