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Updated: May 18, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Is the cognitive-behavioral therapy an effective intervention to prevent the postnatal depression? A critical review
Bernardo Nardi1, Sabrina Laurenzi, Marzia Di Nicolò
1Polytechnic University of Marche, Ancona, Italy. Sabrina.1980@tiscali.it
Objective:
The aim of this article is to review and discuss the efficacy of the Cognitive-Behavioral Therapy (CBT), in the prevention of postnatal depression (PD) in pregnant women at risk.
Method:
PubMed, Medline, PsychInfo, Embase, and the Cochrane Library databases were searched from February 1991 to February 2011.
Results:
Eight Randomized Controlled Trials (RCT) on the prevention of PD with the CBT were selected and their data were analyzed. The literature analyzed recommends that depression in pregnancy requires an efficient management to provide mother's symptoms relief as well as to prevent the PD. While several studies demonstrated the efficacy of the CBT in the treatment of PD, the efficacy of the CBT in preventing PD in pregnant women at risk has been investigated only by a few studies, presenting a number of methodological flaws.
Conclusions:
Better designed RCT are needed to support the efficacy of such psychotherapeutic preventive strategy in women at risk for PD.
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