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Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind, placebo-controlled study
Gaurang R Shah1, Manojkumar V Chaudhari, Suresh B Patankar
1Jivdaya Hospital, Dharmoday bldg, Jivdaya lane, L.B.S. Marg, Ghatkopar (West), Mumbai 400 086, India.
BMC Complementary and Alternative Medicine
|September 18, 2012
Summary
VigRX Plus significantly improved male sexual function, including erectile function, desire, and satisfaction, compared to placebo. This herbal supplement was well-tolerated with no significant difference in side effects.
Area of Science:
- Male Sexual Health
- Herbal Medicine Efficacy
- Clinical Trial Research
Background:
- Limited evidence exists for multi-ingredient herbal supplements in treating male sexual dysfunction.
- VigRX Plus (VXP) is a proprietary polyherbal preparation marketed for enhancing male sexual function.
Purpose of the Study:
- To evaluate the safety and efficacy of VigRX Plus (VXP) in men with mild to moderate erectile dysfunction (ED).
Main Methods:
- A double-blind, randomized, placebo-controlled, multi-center study involving 78 men aged 25-50 with mild to moderate ED.
- Participants received VXP or placebo twice daily for 12 weeks.
- Efficacy was assessed using the International Index of Erectile Function (IIEF) as the primary outcome, along with EDITS, serum testosterone, semen analysis, and global assessments.
Main Results:
- VXP significantly improved IIEF-Erectile Function (EF) scores compared to placebo (P < 0.0001).
- All domains of the IIEF, including orgasmic function, sexual desire, and satisfaction, showed significant improvement with VXP.
- VXP demonstrated significantly higher Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) scores for both patients and partners (P < 0.001).
- 90% of subjects in the VXP group wished to continue treatment, compared to 3% in the placebo group.
- Tolerability and side effect incidence were similar between VXP and placebo groups.
Conclusions:
- VigRX Plus is a well-tolerated and effective option for improving sexual function in men.
- The study supports the therapeutic claims of VXP for enhancing male sexual health.
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