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Multiple system atrophy with early cognitive deficits: a case report.

Simona Spaccavento1, Marina Del Prete, Anna Loverre

  • 1a IRCCS S. Maugeri Foundation , Cassano Murge , Italy.

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Summary
This summary is machine-generated.

Early-stage multiple system atrophy with cerebellar ataxia (MSA-C) shows subtle cognitive deficits, particularly in executive functions, despite normal daily functioning. Comprehensive neuropsychological testing is crucial for early detection and intervention in MSA-C patients.

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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Multiple System Atrophy with predominant Cerebellar Ataxia (MSA-C) is a progressive neurodegenerative disorder.
  • Cognitive deficits are typically reported later in the disease progression of MSA-C.

Observation:

  • A patient in the early stage of MSA-C underwent a comprehensive neuropsychological assessment.
  • Instrumental examinations and daily life activities did not reveal significant impairments.

Findings:

  • The patient exhibited deficits in executive functions, including response inhibition, planning, and reasoning.
  • Memory and visuoconstructional abilities were also affected, despite preserved functional autonomy.
  • MRI revealed cerebellar and brainstem involvement, with normal cerebral structures.

Implications:

  • Early and comprehensive neuropsychological evaluation is vital for detecting subtle cognitive impairments in early MSA-C.
  • Identifying these deficits can facilitate timely initiation of rehabilitation programs.
  • Disruption in cerebro-cerebellar connections may underlie early cognitive deficits in MSA-C.