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Review of spinal neuroectodermal tumor.

Ashis Patnaik¹, Sudhansu S Mishra, Sanjib Mishra

¹Department of Neurosurgery, SCB Medical College & Hospital, Cuttack, Odisha, India. dr_ash007@yahoo.co.in

British Journal of Neurosurgery

|September 18, 2012

Summary

Primary spinal primitive neuroectodermal tumors (PNETs) are aggressive, rare cancers in young people. Despite aggressive treatment, the prognosis for spinal PNETs remains poor.

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Area of Science:

Neuro-oncology
Pediatric Oncology
Spinal Cord Tumors

Background:

Primary spinal primitive neuroectodermal tumors (PNETs) are rare and aggressive neoplasms.
These tumors predominantly affect children and young adults.
Only 47 cases have been documented in medical literature.

Observation:

PNETs exhibit rapid growth and a poor prognosis, even with multimodal therapy.
Two thoracic extradural PNET cases with intrathoracic extension are presented.
These tumors mimicked neurofibroma due to their extension through intervertebral foramina.

Findings:

Both patients underwent gross total resection of intraspinal and thoracic components.
Adjuvant therapy included cranio-spinal radiotherapy for both cases.
One patient survived 8 months post-treatment, while the other succumbed after 4 months.

Implications:

The study highlights the aggressive nature and poor prognosis of primary spinal PNETs.
Multimodal treatment including surgery and radiotherapy offers limited survival benefits.
Further research is needed to improve outcomes for this rare and aggressive tumor type.

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