Nonlinear ultrasound: potential of the cross-correlation method for osseointegration monitoring

Recently the concept of probing nonlinear elasticity at an interface prosthesis/bone has been proposed as a promising method to monitor the osseointegration/sealing of a prosthesis. However, the most suitable method to achieve this goal is a point of debate. To this purpose, two approaches termed the scaling subtraction method and the cross-correlation method are compared here. One nonlinear parameter derived from the cross-correlation method is as sensitive as a clinical device based on linear elasticity measurement. Further, this study shows that cross-correlation based methods are more sensitive than those based on subtraction/addition, such like pulse inversion and similar methods.