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Related Concept Videos

Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Goiter01:27

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

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Related Experiment Video

Updated: May 18, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Do the calcifications in the thyroid gland predict malignancy?

B Gungor1, A K Polat, C Polat

  • 1Department of General Surgery, Ondokuz Mayis University, Samsun, Turkey. bgungor@omu.edu.tr

Bratislavske Lekarske Listy
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Thyroid gland microcalcifications are significant indicators of malignant thyroid disease. These calcifications warrant thorough evaluation using diagnostic imaging and consideration for surgical intervention.

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Area of Science:

  • Endocrinology
  • Oncology
  • Radiology

Background:

  • Thyroid gland calcifications are frequently observed.
  • The association between calcifications and thyroid malignancy requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between thyroid gland calcifications and malignant thyroid lesions.
  • To determine if calcifications can predict the presence of thyroid cancer.

Main Methods:

  • Retrospective analysis of 169 patients undergoing thyroidectomy between June 2005 and May 2010.
  • Evaluation of demographic, ultrasonographic, and histopathologic findings.
  • Statistical analysis using Z-test and Chi-square test to determine the relationship between calcifications and lesion type.

Main Results:

  • Microcalcifications were present in 31.95% of patients; macrocalcification in 0.59%.
  • Malignancy was diagnosed in 17.16% of all patients.
  • The rate of malignancy was significantly higher in patients with calcifications (30.91%) compared to those without (10.52%) (p < 0.001).
  • Calcification was found in 58.62% of malignant cases.

Conclusions:

  • Thyroid gland microcalcifications serve as a potential predictor of malignant thyroid disease.
  • These findings emphasize the need for rigorous evaluation of microcalcifications with diagnostic modalities.
  • Surgical treatment should be considered in cases with suspicious microcalcifications.