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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

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Published on: December 9, 2015

Multiple sclerosis relapses and depression.

Phil Moore1, Claire Hirst, Katharine E Harding

  • 1Helen Durham Neuro-inflammatory Centre, Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, UK.

Journal of Psychosomatic Research
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

High rates of depression occur during multiple sclerosis (MS) relapses. While symptoms may improve, depression often persists long-term, indicating a need for further research and interventions.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Neurology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Depression is a common comorbidity in MS patients.
  • MS relapses can significantly impact mental health.

Purpose of the Study:

  • To investigate the prevalence of depression symptoms during and after MS relapses.
  • To examine the time course of depression symptoms post-relapse.
  • To determine the influence of disability on depression symptom trajectory.

Main Methods:

  • 132 patients with MS relapses were recruited.
  • Depression symptoms (Hospital Anxiety and Depression Scale depression subscale: HADS-D) and disability (Expanded Disability Status Scale: EDSS) were assessed at relapse (0 months) and at 2 and 6 months post-relapse.
  • Statistical analysis was performed to determine prevalence and associations.

Main Results:

  • The prevalence of possible depression (HADS-D ≥ 8) was 44.5% during relapse, decreasing to 29.2% at 2 months and 34.4% at 6 months post-relapse.
  • Depression scores were significantly lower at follow-up compared to during relapse.
  • Depression at relapse was a strong predictor of depression at 2 and 6 months post-relapse. Improvement in EDSS was associated with lower depression likelihood.

Conclusions:

  • High rates of depression are present during MS relapses.
  • Despite significant reductions post-relapse, depression rates remain elevated.
  • Depression symptoms can become persistent after relapse, influenced by disability status, suggesting a need for targeted psychological interventions.