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Related Concept Videos

Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
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Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
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Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes: Management and Pharmacotherapy01:15

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Related Experiment Video

Updated: May 18, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
06:13

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Published on: December 1, 2023

Cost-effectiveness of exercise programs in type 2 diabetes.

Doug Coyle1, Kathryn Coyle, Glen P Kenny

  • 1University of Ottawa, Ontario, Canada. dcoyle@uottawa.ca

International Journal of Technology Assessment in Health Care
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Supervised exercise programs for type 2 diabetes improve health outcomes. A combined resistance and aerobic exercise program offers the most cost-effective approach, demonstrating efficient use of healthcare resources.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Exercise Physiology

Background:

  • Supervised, facility-based exercise training improves glycemic control in type 2 diabetes.
  • These programs incur additional costs, necessitating cost-effectiveness evaluations.
  • The Diabetes Aerobic and Resistance Exercise (DARE) trial provides data for this analysis.

Purpose of the Study:

  • To assess the cost-effectiveness of different supervised exercise programs for type 2 diabetes.
  • To compare resistance, aerobic, and combined exercise programs against a no-exercise control group.
  • To determine the most economically viable exercise intervention for diabetes management.

Main Methods:

  • Utilized data from the DARE clinical trial comparing resistance, aerobic, combined exercise, and control groups.
  • Employed the UKPDS economic model for type 2 diabetes, adapted for the Canadian context.
  • Estimated life-years, quality-adjusted life-years (QALYs), and costs for each patient group.

Main Results:

  • The combined exercise program yielded the highest QALYs (8.94) but also the highest cost ($40,050).
  • The incremental cost per QALY gained was $4,792 for combined vs. aerobic exercise.
  • Sensitivity analysis confirmed the cost-effectiveness of the combined exercise program across various scenarios.

Conclusions:

  • A combined resistance and aerobic exercise program is the most cost-effective intervention for type 2 diabetes.
  • Supervised exercise training for individuals with diabetes represents an efficient allocation of healthcare resources.
  • These findings support the integration of comprehensive exercise programs into diabetes care guidelines.