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Clinically significant anti M antibodies--a report of two cases
Gagandeep Kaur1, Sabita Basu, Paramjit Kaur
1Department of Transfusion Medicine, Government Medical College and Hospital, Sector-32, Chandigarh 160032, India. docvpsingh@yahoo.co.in
Introduction:
Most anti-M antibodies are not active at 37°C and are thus of no clinical significance. Occasionally these antibodies have a wide thermal range and can lead to hemolytic transfusion reactions or hemolytic disease of the new born.
Patient And Methods:
We describe two cases of anti-M antibodies, both of which were clinically significant.
Results:
The first case was detected due to crossmatch incompatibility and the second presented as a blood group discrepancy.
Conclusion:
When the antibody is active at 37°C, M antigen negative red cell units should be issued.
