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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Law of Segregation01:49

Law of Segregation

When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
Genetic Material01:20

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Monohybrid Crosses01:20

Monohybrid Crosses

Overview

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Related Experiment Video

Updated: May 18, 2026

OnePot PURE Cell-Free System
08:25

OnePot PURE Cell-Free System

Published on: June 23, 2021

Pure genes, pure genius.

Steven L McKnight1

  • 1Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390-9152, USA. steven.mcknight@utsouthwestern.edu

Cell
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Donald Brown and Tom Maniatis revolutionized biological and medical science through gene purification and study. Their work, utilizing physical and molecular methods, has profoundly impacted research for over 40 years.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Pioneering research in gene purification and study.
  • Development of physical and molecular biological methodologies.

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  • Significant contributions to biological and medical sciences over four decades.