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SnapShot: membrane curvature sensors and generators

Hongying Shen1, Michelle Pirruccello, Pietro De Camilli

  • 1Department of Cell Biology, Howard Hughes Medical Institute, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA.

Cell
|September 18, 2012
PubMed
Summary

No abstract available in PubMed .

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The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...