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Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
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Integration of retroviral vectors

Richard Gabriel1, Manfred Schmidt, Christof von Kalle

  • 1Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

Current Opinion in Immunology
|September 18, 2012
PubMed
Summary

Retroviral vectors integrate into host genomes, but target site selection mechanisms remain unclear. Understanding viral integrase and host protein interactions is key to improving gene therapy safety by controlling integration sites.

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