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Oxidized high-density lipoprotein is associated with increased plasma glucose in non-diabetic dyslipidemic subjects

Kazuhiko Kotani1, Naoki Sakane2, Masashi Ueda3

  • 1Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto-City, Kyoto 612-8555, Japan; Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan; Lipoprotein Metabolism Section, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1508, USA.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 18, 2012
PubMed

Insights

High plasma glucose may increase oxidized high-density lipoprotein (oxHDL) levels, even in non-diabetic individuals with dyslipidemia. Oxidized HDL may serve as a marker for dysfunctional HDL particles.

Area of Science:

  • Cardiovascular disease research
  • Lipid metabolism and atherosclerosis

Background:

  • Oxidized high-density lipoprotein (oxHDL) exhibits diminished cholesterol efflux and anti-atherogenic properties.
  • The precise role of oxHDL in cardiometabolic disease pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the association between oxHDL levels and plasma glucose (PG) in non-diabetic dyslipidemic subjects.
  • To explore the relationship of oxHDL with other atherosclerotic risk factors.

Main Methods:

  • 155 non-diabetic dyslipidemic subjects were analyzed for conventional atherosclerotic markers and LDL particle size (LDL-PS).
  • Serum oxHDL levels were quantified using a specific antibody in a sandwich ELISA format.

Main Results:

  • oxHDL was independently and positively correlated with fasting plasma glucose (PG).
  • Subjects with the highest PG tertile showed approximately 30% higher oxHDL levels compared to the lowest tertile.
  • HDL-cholesterol showed independent positive correlations with LDL-PS and oxHDL.

Conclusions:

  • Elevated PG levels may promote HDL oxidation, independent of HDL-cholesterol, in non-diabetic dyslipidemic individuals.
  • oxHDL measurement could be a valuable indicator of dysfunctional HDL.
Abstract

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