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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: May 18, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Cancer stem cells.

Zuoren Yu1, Timothy G Pestell, Michael P Lisanti

  • 1Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. zuoren.yu@tongji.edu.cn

The International Journal of Biochemistry & Cell Biology
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) possess self-renewal and tumor-initiating abilities, driving metastasis and treatment resistance. Targeting CSCs, particularly their microRNA regulation and epithelial-mesenchymal transition, offers a promising strategy for novel anti-cancer drug discovery.

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Last Updated: May 18, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
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Published on: May 11, 2016

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cancer stem cells (CSCs) are a distinct tumor subpopulation.
  • CSCs exhibit self-renewal, differentiation, and tumorigenicity.
  • Cell surface markers like CD44, CD24, and CD133 identify CSCs.

Purpose of the Study:

  • To review the current understanding of CSCs.
  • To focus on the role of microRNAs (miRNAs) and epithelial-mesenchymal transition (EMT) in CSCs.
  • To discuss the clinical applications of targeting CSCs.

Main Methods:

  • Literature review of CSCs, miRNAs, signaling pathways (Wnt/β-catenin, Notch, Hedgehog), and EMT.
  • Analysis of CSC resistance to conventional therapies.
  • Exploration of CSCs as a target for anti-cancer drug development.

Main Results:

  • CSCs are resistant to chemotherapy and radiation.
  • CSCs are implicated in cancer metastasis.
  • miRNAs and signaling pathways regulate CSC properties.

Conclusions:

  • CSCs are critical drivers of tumor progression and metastasis.
  • Targeting CSCs represents a key strategy for effective cancer treatment.
  • Understanding miRNA and EMT roles is vital for developing novel anti-cancer therapies.