Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

Perceiving Loudness, Pitch, and Location

Perceiving Loudness, Pitch, and Location

The human brain perceives pitch through two primary mechanisms reflected in place theory and frequency theory. Each mechanism describes how sound waves are interpreted as specific pitches by the brain, offering insights into the intricate processes of auditory perception.
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Using machine learning to predict perfusionists' critical decision-making during cardiac surgery.

Computer methods in biomechanics and biomedical engineering. Imaging & visualization·2022

Same author

[The study about the role of laryngopharyngeal reflux for the hemorrhage after tonsillectomy].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2018

Same author

[Survey of prevalence of iron deficiency and iron deficiency anemia in pregnant women in urban areas of China].

Zhonghua fu chan ke za zhi·2018

Same author

Risk factors of postoperative complications after emergency repair of incarcerated groin hernia for adult patients: a retrospective cohort study.

Hernia : the journal of hernias and abdominal wall surgery·2018

Same author

Tacrolimus, not triamcinolone acetonide, interacts synergistically with itraconazole, terbinafine, bifonazole, and amorolfine against clinical dermatophyte isolates.

Journal de mycologie medicale·2018

Same author

MicroRNA-203 inhibits invasion and induces apoptosis of laryngeal cancer cells via targeting LASP1.

European review for medical and pharmacological sciences·2018

Search research articles

Related Experiment Video

Updated: May 18, 2026

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Published on: December 20, 2024

Binaural speech processing in individuals with auditory neuropathy.

G Rance¹, M M Ryan, P Carew

¹The University of Melbourne, Department of Audiology & Speech Pathology, Parkville, Melbourne, Australia. grance@unimelb.edu.au

|September 18, 2012

Summary

Auditory neuropathy impairs binaural hearing, affecting speech perception in noise. This deficit is linked to timing issues in auditory nerves and overall disease severity in neuropathic disorders.

More Related Videos

Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique

Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique

Published on: September 7, 2022

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

Published on: March 13, 2026

Related Experiment Videos

Last Updated: May 18, 2026

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Published on: December 20, 2024

Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique

Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique

Published on: September 7, 2022

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

Published on: March 13, 2026

Area of Science:

Neuroscience
Audiology
Genetics

Background:

Auditory neuropathy disrupts neural sound processing, impacting inter-aural integration.
Axonal (Friedreich ataxia) and demyelinating (Charcot-Marie-Tooth disease type 1A) neuropathies affect auditory pathways.

Purpose of the Study:

Investigate binaural auditory processing in Friedreich ataxia and Charcot-Marie-Tooth disease type 1A.
Correlate auditory deficits with clinical severity in neuropathic disorders.

Main Methods:

Psychophysical evaluation of basic auditory processing (intensity discrimination, temporal resolution).
Binaural speech perception assessment using the Listening in Spatialized Noise test.
Comparison with age, gender, and hearing-level-matched controls.

Main Results:

Individuals with auditory neuropathy showed impaired speech perception in noise across conditions.
Spatial cue utilization was linked to temporal resolution, indicating disordered timing cues.
Impaired spatial processing correlated with overall disease severity (Friedreich Ataxia Rating Scale, Charcot-Marie-Tooth Neuropathy Score).

Conclusions:

Binaural speech processing deficits in auditory neuropathy stem from disordered neural timing.
Auditory dysfunction reflects generalized neuropathic changes.
Binaural speech processing measures are promising for clinical neurology, tracking disease progression and intervention efficacy.