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Quaternized chitosan-organic rectorite intercalated composites based nanoparticles for protein controlled release
Ruifen Xu1, Shangjing Xin, Xue Zhou
1Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
International Journal of Pharmaceutics
|September 18, 2012
Summary
Organic rectorite (OREC) enhances quaternized chitosan (QC)/alginate (ALG) nanoparticles for protein delivery. These novel nanoparticles show improved encapsulation and controlled release, offering a promising drug delivery system.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Chitosan and alginate are widely used biopolymers for nanoparticle fabrication.
- Developing effective controlled release systems for proteins remains a significant challenge in pharmaceutical research.
- Organic rectorite (OREC) is a novel material with potential applications in advanced material science.
Purpose of the Study:
- To fabricate novel quaternized chitosan (QC)/alginate (ALG) nanoparticles incorporating organic rectorite (OREC) for protein encapsulation.
- To investigate the morphology, structure, and drug loading capabilities of the OREC-modified nanoparticles.
- To evaluate the in vitro release kinetics of encapsulated proteins from the composite nanoparticles.
Main Methods:
- Ionic gelation method was employed to synthesize QC/ALG/OREC composite nanoparticles.
- Fourier transform infrared spectra, energy dispersive X-ray, X-ray photoelectron spectroscopy, and small angle X-ray diffraction were used for characterization.
- Size distribution analysis and in vitro release studies in simulated gastric and intestinal fluids were conducted.
- Bovine serum albumin was used as a model protein drug for encapsulation studies.
Main Results:
- The incorporation of OREC into QC/ALG nanoparticles was confirmed through various spectroscopic and diffraction techniques.
- Nanoparticle encapsulation efficiency increased from 21.2% to 44.9% with OREC addition.
- Loading capacity significantly improved from 13.7% to 25.0% upon OREC incorporation.
- In vitro release studies demonstrated a marked reduction in initial burst release, from 20.15% to 11.07% in gastric fluid and 14.69% to 4.52% in intestinal fluid.
Conclusions:
- Organic rectorite (OREC) effectively enhances the properties of quaternized chitosan (QC)/alginate (ALG) nanoparticles for protein delivery.
- The OREC-modified nanoparticles exhibit superior encapsulation efficiency and loading capacity.
- These composite nanoparticles demonstrate significantly improved controlled release profiles, inhibiting rapid initial drug release.
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