Related Experiment Video
Updated: May 18, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via
Ravendra Singh1, Marianthi Ierapetritou, Rohit Ramachandran
1Engineering Research Center for Structured Organic Particulate Systems, Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Abstract:
A novel manufacturing strategy based on continuous processing integrated with online monitoring tools coupled with efficient automatic feedback control system is highly desired for efficient Quality by Design (QbD) based manufacturing of the next generation of pharmaceutical products with optimal consumption of time, space and resources. In this manuscript, an efficient plant-wide control strategy for an integrated continuous pharmaceutical tablet manufacturing process via roller compaction has been designed in silico. The designed control system consists of five cascade control loops and three single control loops resulting in 42 controller tuning parameters. An effective controller parameter tuning strategy involving an ITAE method coupled with an optimization strategy has been proposed and the designed control system has been implemented in a first principle model-based flowsheet that was simulated in gPROMS (Process System Enterprise). The advanced techniques (e.g. anti-windup) have been employed to improve the performance of the control system. The ability of the control system to reject the unknown disturbances as well as to track the set point has been analyzed. Results demonstrated enhanced performance of critical quality attributes (CQAs) under closed-loop control compared to open-loop operation thus illustrating the potential of closed-loop feedback control in improving pharmaceutical manufacturing operations.
Related Concept Videos
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Oral Drug Delivery Systems: Continuous-Release Systems
Modified-Release Drug Delivery Systems: Rate-Programmed II
In Vitro Drug Dissolution: Compendial Testing Models I

