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Related Experiment Videos

Centrosome competition: a possibility?

G Marin1, F Argenton

  • 1Dipartimento di Biologia, Università di Padova, Italia.

Experimental Cell Research
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

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Centrosome competition may drive the evolution of sexual reproduction. Studies on fused hamster cells show more multipolar mitoses when similar centrosomes fuse, suggesting competition is less likely between dissimilar ones.

Area of Science:

  • Cell Biology
  • Evolutionary Biology
  • Genetics

Background:

  • A novel theory proposes that heritable variations in centrosome function drive the evolution of sexuality.
  • This theory suggests that competition for mitotic spindle organization occurs when centrosomes from different cells merge within a shared cytoplasm.

Purpose of the Study:

  • To investigate the hypothesis of centrosome competition in the context of evolution of sexuality.
  • To indirectly support the theory of centrosome competition using experimental data from cultured cells.

Main Methods:

  • Creation of polykaryocytes (cells with multiple nuclei) using polyethylene glycol (PEG) in cultured Chinese hamster fibroblasts.
  • Comparison of multipolar mitosis frequencies in fused cell cultures under two conditions: favoring fusion of related (sib) cells versus distantly related cells.

Related Experiment Videos

  • Assumption that sib centrosomes are more similar than centrosomes from distantly related cells.

    • Main Results:

    • Multipolar mitoses were significantly more frequent when cultures favored the fusion of sib cells.
    • This observation supports the idea that centrosome competition is less effective when centrosomes are highly similar.

    Conclusions:

    • The findings indirectly support the theory of centrosome competition.
    • Heritable variation in centrosome properties may play a role in the evolution of sexual reproduction.
    • The degree of similarity between centrosomes influences the likelihood of competition and subsequent multipolar divisions.