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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
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The immune system and developmental programming of brain and behavior.

Staci D Bilbo1, Jaclyn M Schwarz

  • 1Department of Psychology and Neuroscience, Duke University, 572 Research Drive, Box 91050, Durham, NC 27708, USA. staci.bilbo@duke.edu

Frontiers in Neuroendocrinology
|September 18, 2012
PubMed
Summary

The immune system critically influences brain development and function throughout life. Early immune activation can impact later neural, immune, mood, and cognitive outcomes, highlighting a crucial link between immunity and neurodevelopmental health.

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Last Updated: May 18, 2026

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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Area of Science:

  • Neuroscience
  • Immunology
  • Endocrinology

Background:

  • The brain, endocrine, and immune systems are interconnected, influencing each other's function.
  • Immune molecules affect neuroendocrine function and hormone-behavior interactions in health and sickness.
  • Hormonal changes, like those during stress, significantly impact immune responses.

Purpose of the Study:

  • To review the critical role of the immune system in brain development.
  • To discuss how early immune activation influences lifelong neural, immune, mood, and cognitive functions.
  • To explore the link between immune dysfunction and neuropsychiatric disorders with neurodevelopmental origins.

Main Methods:

  • This is a review article, synthesizing existing research.
  • The review focuses on established scientific literature and evidence.
  • Key concepts discussed include neuroendocrine-immune interactions and neurodevelopmental impacts.

Main Results:

  • The developing brain is highly sensitive to immune signals.
  • Immune system activity during early development has lasting effects on an individual's health.
  • Disruptions in this early interplay are associated with neuropsychiatric conditions.

Conclusions:

  • The immune system plays a vital role in shaping brain development and lifelong outcomes.
  • Understanding these interactions is crucial for addressing neurodevelopmental and neuropsychiatric disorders.
  • Early life immune events can have profound and enduring consequences on brain and behavior.