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Updated: May 18, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Role of estrogen receptor β in gynecological cancer
Julia Häring1, Susanne Schüler, Claus Lattrich
1Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany.
Abstract:
Estrogen receptor β is expressed in normal and neoplastic ovarian and endometrial tissues. Recent studies indicate that levels of this receptor decline in ovarian tumorigenesis, like in breast or prostate cancer. Furthermore, ERβ expression has been associated with good prognosis in ovarian cancer. In contrast, previous studies on the role of this receptor in endometrial cancer suggested that ERβ might play different roles in the carcinogenesis of the ovary and endometrium. Besides its possible role as a prognostic factor, ERβ might be a potential target for the treatment of ovarian and endometrial cancer.
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