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Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Cancer-Critical Genes I: Proto-oncogenes01:33

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In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
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Being young, female, and BRCA positive.

Rebekah Hamilton1

  • 1College of Nursing, Rush University, Chicago, IL, USA. rebekah_hamilton@rush.edu

The American Journal of Nursing
|September 18, 2012
PubMed
Summary

Young women with BRCA mutations face unique psychosocial challenges regarding relationships and childbearing. Understanding these impacts is crucial for healthcare providers supporting these individuals.

Area of Science:

  • Genetics and Oncology
  • Psychosocial Health
  • Women's Health

Background:

  • Women with BRCA1 or BRCA2 mutations have an increased risk of early-onset breast and ovarian cancers.
  • Limited understanding exists regarding the psychosocial effects of these mutations on young women, particularly concerning marriage and childbearing.

Purpose of the Study:

  • To explore the psychosocial consequences of carrying BRCA1 or BRCA2 mutations in young women.
  • To investigate how genetic risk knowledge impacts marital and childbearing decisions in this demographic.

Main Methods:

  • Qualitative study involving 44 women aged 18-39 who tested positive for BRCA mutations.
  • Data collected through phone or email interviews in 2006.
  • Grounded theory analysis focused on participants' age, genetic testing status, marital status, parental status, and breast cancer diagnosis.

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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

Main Results:

  • Unmarried participants discussed challenges in disclosing genetic risk information within relationships.
  • Mothers prioritized 'staying alive' for their children, while childless women felt an urgency to have children.
  • Knowledge of genetic risk influenced prophylactic mastectomy decisions in women diagnosed with breast cancer.

Conclusions:

  • Young women with BRCA mutations experience feelings of isolation and misunderstanding.
  • Healthcare providers, especially nurses, need to address the specific psychosocial needs related to marriage and childbearing in this population.