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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
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Osteoclasts in Bone Remodeling

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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Obtaining Primary Osteocytes Through Murine Calvarial Fractionation of GFP-Expressing Osteocytes
07:22

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Published on: June 2, 2020

FGF23 production by osteocytes.

Lynda F Bonewald1, Michael J Wacker

  • 1School of Dentistry, University of Missouri, 650 East 25th Street, Kansas City, MO, 64108-2784, USA. bonewaldl@umkc.edu

Pediatric Nephrology (Berlin, Germany)
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 23 (FGF23) regulates phosphate balance. This review explores FGF23 in osteocytes, its link to chronic kidney disease, and cardiovascular risks.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Bone Biology

Background:

  • Fibroblast growth factor 23 (FGF23) is a bone-derived hormone crucial for phosphate homeostasis.
  • Elevated FGF23 levels are observed in chronic kidney disease (CKD) patients and animal models.
  • High FGF23 is associated with vascular dysfunction, calcification, and cardiovascular disease (CVD) risk.

Purpose of the Study:

  • To review FGF23 expression within osteocytes.
  • To discuss potential regulatory mechanisms of FGF23 expression and function at the osteocyte level.
  • To explore the role of osteocyte-derived FGF23 in CKD and associated cardiovascular complications.

Main Methods:

  • Literature review of studies on FGF23, osteocytes, CKD, and cardiovascular disease.
  • Analysis of existing data on FGF23 regulation in bone cells.
  • Synthesis of findings linking FGF23 to phosphate metabolism and vascular health.

Main Results:

  • Osteocytes are a primary source of FGF23, targeting the kidney.
  • FGF23 levels are elevated in osteocytes and systemically in CKD.
  • FGF23 contributes to vascular complications in CKD.

Conclusions:

  • Osteocyte FGF23 plays a significant role in phosphate homeostasis and CKD pathogenesis.
  • Understanding osteocyte FGF23 regulation may offer therapeutic targets for CKD and CVD.
  • Further research into osteocyte-specific FGF23 modulation is warranted.