Dihydropyridines on guinea-pig ileum
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Updated: Oct 2, 2026

Gastrointestinal Motility Monitor (GIMM)
Published on: December 1, 2010
I Martin1, I Colado, V del Val
1Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
Abstract:
1. The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM). 3. From these experiments it is concluded that nimodipine and nitrendipine, like nifedipine, produced a similar and potent inhibitory effect of the contractile responses induced in the guinea-pig ileum. 4. Nisoldipine resulted to be the most active agent.
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