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Updated: May 18, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Epstein-barr virus and the pathogenesis of T and NK lymphoma: a mystery unsolved
Lindsay C George1, Martin Rowe, Christopher P Fox
1School of Cancer Sciences, College of Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Abstract:
The potent growth-transforming properties of Epstein-Barr virus (EBV) and its role in pathogenesis of a range of B cell and epithelial malignancies are well established. By contrast, the association of this B lymphotropic virus with malignancies of T and NK cell origin was entirely unexpected. Although a number of mature T and NK lymphoma subtypes have been associated with EBV, evidence for a robust viral/tumour relationship is principally limited to extranodal NK/T lymphoma (ENKTL). Despite progress in diagnosis and classification, alongside an evolving understanding of ENKTL pathobiology, EBV's contribution to lymphomagenesis remains largely unresolved. Challenges relate to the rarity of this entity, a lack of clinical and biological correlative data and scarcity of fresh tissue for molecular and functional studies. Nonetheless, recent studies on viral and cellular gene expression have permitted new avenues of investigation into ENKTL pathobiology aiming to extend our understanding of disease biology and ultimately improve clinical outcomes.
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