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Anti-Müllerian hormone serum values and ovarian reserve: can it predict a decrease in fertility after ovarian
Tito Silvio Patrelli1, Salvatore Gizzo, Nicoletta Sianesi
1Department of Gynecology, Obstetrics and Neonatology, University of Parma, Parma, Italy. titosilvio.patrelli@gmail.com
Plos One
|September 18, 2012
Summary
Serum anti-Mullerian hormone (AMH) levels can predict ovarian response in women undergoing assisted reproductive technology (ART) cycles. Monitoring AMH is crucial for customizing ART protocols and assessing potential decreases after IVF.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization
- Ovarian Physiology
Background:
- Ovarian stimulation success can be predicted by biomarkers like anti-Mullerian hormone (AMH).
- Assessing AMH's utility in predicting ovarian response and reproductive outcomes in women undergoing assisted reproduction technology (ART) cycles is important.
Purpose of the Study:
- To confirm the clinical usefulness of serum anti-Mullerian hormone (AMH) assay in predicting ovarian response and reproductive outcome in women undergoing ART cycles.
- To evaluate the correlation between AMH levels and various parameters of ovarian stimulation and ART outcomes.
Main Methods:
- Recruited 46 women aged <42 years undergoing ART cycles with specific inclusion criteria (BMI 20-25, regular cycles, basal FSH <12 IU/L, basal estradiol <70 pg/mL).
- Administered FSH stimulation with GnRH-agonist/GnRH-antagonist protocols, categorizing responders (poor: ≤3 oocytes, normal: 4-9, high: ≥10).
- Collected serum samples for AMH assays on the first and last days of stimulation, with statistical significance set at P ≤ 0.05.
Main Results:
- Decreased AMH levels correlated with increased FSH levels; AMH correlated significantly with the number of follicles, estradiol levels on hCG day, and retrieved oocytes.
- AMH levels significantly correlated with the number of fertilized oocytes but not with obtained or transferred embryos.
- Basal AMH levels were higher than on hCG day, and significant correlations were found between AMH levels across different responder categories (normal, high, and poor).
Conclusions:
- Serum AMH is clinically useful for customizing ART treatment protocols.
- The study suggests the necessity of monitoring for potential permanent decreases in AMH levels following IVF treatment.
- AMH serves as a valuable biomarker for predicting ovarian response and guiding ART interventions.
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