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Related Experiment Video

Updated: May 18, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Lupoid cutaneous leishmaniasis: a case report.

Aida Khaled1, Samia Goucha, Sonia Trabelsi

  • 1Department of Dermatology, Charles Nicolle Hospital, Boulevard 9 Avril, 1006 Tunis, Tunisia.

Dermatology and Therapy
|September 18, 2012
PubMed
Summary
This summary is machine-generated.

Lupoid cutaneous leishmaniasis (CL), a rare facial condition mimicking other granulomatous diseases, was diagnosed via microscopic examination. Treatment with fluconazole proved effective after initial intolerance to meglumine antimoniate.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Parasitology

Background:

  • Lupoid cutaneous leishmaniasis (CL) is a rare manifestation of CL.
  • It presents with facial lesions resembling other granulomatous conditions.
  • Early diagnosis and appropriate treatment are crucial for patient outcomes.

Purpose of the Study:

  • To present a case of lupoid CL.
  • To discuss diagnostic tools for this parasitic infection.
  • To review differential diagnoses and treatment strategies.

Main Methods:

  • A case report of a 54-year-old woman with a facial plaque.
  • Diagnosis confirmed by microscopic examination of leishmania parasites.
  • Treatment involved fluconazole after intolerance to meglumine antimoniate.

Main Results:

  • Microscopic examination confirmed numerous leishmania parasites (amastigote form) within monocytes.
  • The patient achieved clinical cure with fluconazole (200 mg/day for 6 weeks).
  • Initial treatment with meglumine antimoniate caused pancreatic intolerance; doxycycline was ineffective.

Conclusions:

  • Lupoid CL is suspected in endemic areas but should be considered in non-endemic regions for facial lesions with tuberculoid histology.
  • Travel history to endemic areas is a key factor in diagnosis.
  • Prompt diagnosis and tailored treatment, like fluconazole, are essential.