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Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

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Related Experiment Video

Updated: May 18, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Granulomatous appendicitis in a child.

John Pohl1, Amy Lowichik, Mark Deneau

  • 1Department of Pediatric Gastroenterology, Primary Children's Medical Center, University of Utah, Salt Lake City, UT 84113-1103, USA. john.pohl@imail.org

Fetal and Pediatric Pathology
|September 19, 2012
PubMed
Summary
This summary is machine-generated.

Granulomatous appendicitis, a rare appendix inflammation, resolved in a pediatric patient after surgery. Microscopic findings suggest it may be a form of inflammatory bowel disease.

Related Experiment Videos

Last Updated: May 18, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Area of Science:

  • Gastroenterology
  • Pathology
  • Pediatric Surgery

Background:

  • Granulomatous appendicitis (GA) is an uncommon inflammatory condition of the appendix.
  • Its exact etiology and relationship to other gastrointestinal disorders remain unclear.

Observation:

  • A pediatric case of GA is presented with symptomatic resolution following appendectomy.
  • Endoscopic examination of the colon appeared normal.
  • However, microscopic analysis revealed colitis.

Findings:

  • The appendix exhibited granulomatous inflammation.
  • The colonic tissue showed inflammation but lacked granulomas.
  • Appendectomy led to the resolution of symptoms in the pediatric patient.

Implications:

  • This case suggests that granulomatous appendicitis might be a manifestation of inflammatory bowel disease (IBD).
  • Further research is warranted to explore the potential link between GA and IBD.
  • Understanding this association could improve diagnostic and therapeutic strategies for both conditions.