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Published on: April 5, 2024
Association between MMP-2 and TIMP-2 gene polymorphisms and advanced-stage endometriosis in Korean women
Yeon Jean Cho1, Nam Hee Kim, Kyung-Ah Jeong
1Department of Obstetrics and Gynecology, Dong-A University School of Medicine, Pusan, South Korea.
Problem:
To characterize the genetic variation across the MMP-2 and TIMP-2 gene with the risk of advanced-stage endometriosis.
Method Of Study:
Ten single-nucleotide polymorphisms (SNPs) and haplotype associations between MMP-2 (9082A>G, 9152A>G, 105330C>T, 14931T>C, 15918T>C, 18796G>A, 19033G>A, 19218A>G, 25190A>G, and 28542C>T) and TMIP-2 gene (42138327C>T, 42141169G>A, 42144611A>G, 42152781C>T, 42155855G>A, 42175617C>T, 42181597G>A, 42183387T>C, 42196041G>C, and 42196430T>C) were examined in 201 patients and 183 controls.
Results:
In MMP-2, G/A haplotype of 9082A>G and 9152A>G in intron 2 was associated with a reduced risk of endometriosis (OR 0.7, 95% CI 0.5-1.0, P = 0.04). In TIMP-2, the CC genotype of 42196430T>C and C/C haplotype of 42196041G>C/42196430T>C in the promoter region showed an increased risk of endometriosis (OR 3.0, 95% CI 1.2-8.0, P = 0.02; OR 1.6, 95% CI 1.1-2.4, P = 0.02), and the CC genotype of 42183387T>C and the C/G/C haplotype of 42175617C>T/42181597G>A/42183387T>C in intron 1 were associated with a reduced risk (OR 0.5, 95% CI 0.3-0.97, P = 0.04; OR 0.6, 95% CI 0.4-0.95, P = 0.03).
Conclusion:
The MMP-2 and TIMP-2 polymorphisms are associated with advanced-stage endometriosis. Especially, the risk of endometriosis was different according to the genetic position in the TIMP-2 gene.
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