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Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
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Gender-specific association between FSHR and PPARG common variants and human longevity
Rosa Maria Corbo1, Alessandro Pinto, Renato Scacchi
1Department of Biology and Biotechnology, La Sapienza University, Rome, Italy. rosamaria.corbo@uniroma1.it
Rejuvenation Research
|September 19, 2012
Summary
Specific gene variants influence longevity differently in men and women. The FSHR 680 Ser/Ser genotype favors longevity in women, while the PPARG Pro/Ala genotype may hinder it in men.
Area of Science:
- Genetics
- Gerontology
- Human Longevity
Background:
- Human longevity exhibits sex-specific differences, with genetic factors playing a role.
- Previous research suggests certain genes, like FSHR and PPARG, may influence lifespan in a gender-specific manner.
Purpose of the Study:
- To investigate the association between longevity and polymorphisms in the follicle-stimulating hormone receptor (FSHR) and peroxisome proliferator-activated receptor gamma (PPARG) genes.
- To determine if these genetic polymorphisms have a gender-specific effect on achieving longevity.
Main Methods:
- Recruited 277 individuals and categorized them into long-lived (over 90 years) and control groups based on 2009 mortality data.
- Analyzed the frequencies of FSHR (Asn680Ser) and PPARG (Pro12Ala) polymorphisms in relation to longevity in men and women.
- Conducted a literature review on gender-specific genetic influences on longevity.
Main Results:
- The FSHR 680 Ser/Ser genotype was more frequent in long-lived women (OR=4.21, p=0.036), suggesting it promotes female longevity.
- The PPARG Pro/Ala genotype was more frequent in men who died before 90 (OR=0.13, p=0.03), indicating it may impede male longevity.
- Literature review suggested genetic factors generally have a greater impact on male longevity than female longevity.
Conclusions:
- The FSHR 680 Ser/Ser genotype appears to be a favorable factor for longevity in women.
- The PPARG Pro/Ala genotype may be associated with reduced lifespan in men.
- Genetic influences on longevity may differ significantly between sexes, with potentially greater relevance in men.
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