Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Design and Control of a 1-DOF MRI Compatible Pneumatically Actuated Robot with Long Transmission Lines.

IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division·2011

Same author

Effect of oxidized low-density lipoprotein concentration polarization on human smooth muscle cells' proliferation, cycle, apoptosis and oxidized low-density lipoprotein uptake.

Journal of the Royal Society, Interface·2011

Same author

Acrolein hydrogenation on Pt(211) and Au(211) surfaces: a density functional theory study.

Physical chemistry chemical physics : PCCP·2011

Same author

Anhydrous proton-conducting membrane based on poly-2-vinylpyridinium dihydrogenphosphate for electrochemical applications.

The journal of physical chemistry. B·2011

Same author

Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.

European journal of medicinal chemistry·2011

Same author

Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry.

Journal of pharmaceutical and biomedical analysis·2011

Same journal

Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

Neuroscience letters·2026

Same journal

Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

Neuroscience letters·2026

Same journal

Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

Neuroscience letters·2026

Same journal

Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

Neuroscience letters·2026

Same journal

Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

Neuroscience letters·2026

Same journal

Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 18, 2026

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

Mental fatigue impairs pre-attentive processing: a MMN study.

Bo Yang¹, Wei Xiao, Xufeng Liu

¹Department of Psychology, The Fourth Military Medical University, Xi'an, Shanxi, China.

Neuroscience Letters

|September 19, 2012

Summary

This summary is machine-generated.

Mental fatigue, induced by cognitive tasks, impairs the brain's ability to detect subtle changes in early sensory processing. This suggests mental fatigue negatively affects pre-attentive information processing.

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

Related Experiment Videos

Last Updated: May 18, 2026

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions

Published on: July 16, 2015

Area of Science:

Cognitive Neuroscience
Psychophysiology

Background:

Prolonged cognitive tasks often lead to mental fatigue.
Understanding how mental fatigue impacts sensory processing is crucial.

Purpose of the Study:

To investigate the effects of mental fatigue on pre-attentive information processing.
To examine changes in the mismatch negativity (MMN) event-related potential (ERP) component.

Main Methods:

Mental fatigue was induced through 2 hours of continuous mental arithmetic tasks.
The mismatch negativity (MMN) component of event-related potentials (ERPs) was recorded using an equiprobable paradigm.
MMN amplitudes were analyzed at fronto-central and temporal electrode sites.

Main Results:

A significant decrease in MMN amplitudes was observed at fronto-central electrode sites in the mental fatigue group compared to controls.
Temporal MMN amplitudes were not significantly affected by mental fatigue.
These findings indicate a specific impairment in early sensory processing due to mental fatigue.

Conclusions:

Mental fatigue impairs the brain's pre-attentive processing capabilities.
The effects of mental fatigue are localized, impacting fronto-central but not temporal MMN.
This research highlights the detrimental effects of cognitive load on fundamental information processing stages.