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Thyroid functions of neonates with Down syndrome
Dilek Sarici1, Mustafa Ali Akin, Selim Kurtoglu
1Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, 38039, Turkey. drdilekcoban@gmail.com
Italian Journal of Pediatrics
|September 19, 2012
Summary
Neonates with Down syndrome frequently exhibit thyroid dysfunction, including hyperthyrotropinemia and iodine imbalances. Early thyroid function screening is crucial for improving development and preventing intellectual decline in these infants.
Area of Science:
- Neonatal endocrinology
- Pediatric thyroid disorders
Background:
- Down syndrome is associated with an increased risk of thyroid abnormalities.
- Evaluating thyroid function and volume in neonates with Down syndrome is important for early detection and management.
Purpose of the Study:
- To assess thyroid function and volume in 80 neonates diagnosed with Down syndrome.
- To identify specific thyroid abnormalities prevalent in this population.
Main Methods:
- Collected data on free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroglobulin, and urinary iodine levels.
- Utilized ultrasonography to measure thyroid volume.
- Analyzed thyroid function tests and ultrasonographic findings.
Main Results:
- Abnormal thyroid function tests were found in 53.8% of neonates.
- Common abnormalities included hyperthyrotropinemia (32 cases), iodine deficiency (12 cases), and iodine overload (4 cases).
- Thyroid volume abnormalities (hypoplasia, agenesis, goiter) were detected in 17 of 36 assessed patients.
Conclusions:
- Routine neonatal screening for thyroid function in Down syndrome is recommended to prevent intellectual deterioration.
- Hyperthyrotropinemia is a significant concern in neonates with Down syndrome and requires careful monitoring.
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