Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 18, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Transitional zone pull through: surgical pathology considerations.

Raj P Kapur1, Amy J Kennedy

  • 1Department of Laboratories, Seattle Children's Hospital, Seattle, WA 98115, USA. raj.kapur@seattlechildrens.org

Seminars in Pediatric Surgery
|September 19, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A single-cell transcriptomic atlas of the pigtail macaque placenta in late gestation.

BMC genomics·2026
Same author

"It's Not a One-Size-Fits-All": Patient Perspectives on Contingency Management and Community Reinforcement Approach for Methamphetamine Use Disorder in Permanent Supportive Housing.

Journal of health care for the poor and underserved·2026
Same author

Contingency Management for the Treatment of Stimulant Use Disorder.

JAMA internal medicine·2026
Same author

A Pilot Evaluation of a Telemedicine Pharmacist-Physician Management Model to Increase Access to Medication for Alcohol and Opioid Use Disorders for Rural Veterans.

The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association·2026
Same author

International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease.

Neurogastroenterology and motility·2026
Same author

How to Care for the Patient With Methamphetamine-Associated Pulmonary Arterial Hypertension.

Chest·2026

Incomplete resection of the transitional zone (TZ) in Hirschsprung disease can lead to postoperative issues. Establishing clear diagnostic criteria for the TZ is crucial for better surgical outcomes and avoiding reoperation.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Histopathology

Background:

  • Incomplete resection of the transitional zone (TZ) in Hirschsprung disease is linked to postoperative dysmotility.
  • Current histopathological criteria for defining the TZ lack standardization and reproducibility.
  • This ambiguity complicates intraoperative margin assessment and impacts patient outcomes.

Purpose of the Study:

  • To review the literature on defining the transitional zone (TZ) in Hirschsprung disease.
  • To highlight the challenges in establishing diagnostic criteria for the TZ.
  • To propose a prudent approach for intraoperative frozen section analysis and emphasize the need for further research.

Main Methods:

  • Literature review of histopathological indexes and diagnostic criteria for the TZ.

More Related Videos

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Related Experiment Videos

Last Updated: May 18, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

  • Analysis of studies on postoperative outcomes after TZ pull through (TZPT).
  • Evaluation of current recommendations for intraoperative frozen section examination of the proximal margin.

    • Main Results:

    • Diverse and non-validated histopathological indexes are used to define the TZ.
    • Inadequate histopathological descriptions in existing studies hinder clinical translation.
    • TZPT is frequently associated with persistent obstructive symptoms requiring reoperation.

    Conclusions:

    • Validated diagnostic criteria for the TZ are urgently needed.
    • A conservative approach using frozen section analysis to exclude specific histopathological findings at the proximal margin is recommended.
    • Further controlled studies are required to correlate proximal margin histology with postoperative outcomes.