Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for the Y(2175) in the Photoproduction Cross Section Measurement of γp→ϕπ^{+}π^{-}p at GlueX.

Physical review letters·2026
Same author

[Analysis of influencing factors for abnormal uterine bleeding due to cesarean scar diverticulum].

Zhonghua fu chan ke za zhi·2026
Same author

Protective effect of mannose oligosaccharides on cadmium-induced hepatic oxidative damage in rats.

Polish journal of veterinary sciences·2025
Same author

Upper Limit on the Photoproduction Cross Section of the Spin-Exotic π_{1}(1600).

Physical review letters·2025
Same author

[Correlation between uterine volume and intrauterine adhesion: a propensity score matching analysis].

Zhonghua fu chan ke za zhi·2025
Same author

[Peripheral neuropathy originating from short stature in 4 children].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2024

Related Experiment Video

Updated: May 18, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules.

D J Pappas1, P A Gabatto, D Oksenberg

  • 1Department of Neurology, University of California, San Francisco, CA 94158, USA. djpappas75@gmail.com

Neuroscience
|September 19, 2012
PubMed
Summary

Glutamate excitotoxicity is implicated in neurodegenerative diseases. This study reveals that the Toll-like receptor (TLR)/interferon regulatory factor 7 (IRF7)/interferon (IFN) axis promotes neuronal survival following excitotoxic injury.

More Related Videos

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Related Experiment Videos

Last Updated: May 18, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
08:14

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Glutamate excitotoxicity is a key factor in neurodegenerative disorders.
  • N-methyl-d-aspartate (NMDA) receptors are potential therapeutic targets for neuroprotection.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying neuroprotection against NMDA-induced excitotoxicity.
  • To identify key genes and pathways involved in neuronal survival.

Main Methods:

  • Primary cortical neurons from mice were cultured and exposed to NMDA.
  • Neuroprotective molecules were applied, and whole genome expression was analyzed via microarray.
  • Database mining, text mining, and systems modeling were used to analyze gene expression data.

Main Results:

  • A core set of genes and pathways, including MAPK, TLR, and HIF, were significantly altered.
  • The Toll-like receptor (TLR) pathway showed enrichment of interferon regulatory factor 7 (IRF7)-regulated genes.
  • IRF7 knockdown reduced neuronal survival, while type-I interferons (IFNs) promoted survival.

Conclusions:

  • The TLR/IRF7/IFN signaling axis plays a crucial role in neuronal recovery from excitotoxicity.
  • Type-I IFNs are sufficient to confer neuroprotection.
  • This axis represents a potential therapeutic target for neurodegenerative diseases.