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Dietary Nrf2 activators inhibit atherogenic processes
1College of Medicine, University of Saskatchewan, SK, Canada; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. bjuurlink@gmail.com
Abstract:
Dietary Nrf2 activators increase expression of phase 2 protein genes in cells undergoing oxidative stress resulting in a lowering of oxidative stress. Oxidative stress promotes atherogenic processes through oxidizing low density lipoproteins and promotion of inflammation through activation of nuclear factor kappa B and activation of mitogen-activated protein kinases. Nrf2 activators by decreasing oxidative stress decrease the probability of developing atherosclerotic lesions.
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