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Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
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NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

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Co-activators and Co-repressors02:04

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Related Experiment Videos

Dietary Nrf2 activators inhibit atherogenic processes.

Bernhard H J Juurlink1

  • 1College of Medicine, University of Saskatchewan, SK, Canada; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. bjuurlink@gmail.com

Atherosclerosis
|September 19, 2012
PubMed
Summary

Dietary Nrf2 activators reduce cellular oxidative stress by boosting phase 2 gene expression. This reduction in oxidative stress may lower the risk of developing atherosclerosis and related inflammatory processes.

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Area of Science:

  • Nutritional biochemistry
  • Molecular biology
  • Cardiovascular disease research

Background:

  • Oxidative stress is a key factor in the development of atherosclerosis.
  • Oxidative stress promotes low-density lipoprotein oxidation and inflammation.
  • Inflammation in atherosclerosis is mediated by pathways like nuclear factor kappa B and mitogen-activated protein kinases.

Purpose of the Study:

  • To investigate the role of dietary Nrf2 activators in mitigating oxidative stress.
  • To explore the potential of Nrf2 activation in preventing atherogenesis.

Main Methods:

  • Assessing the effect of Nrf2 activators on phase 2 gene expression.
  • Evaluating the impact of Nrf2-mediated changes on oxidative stress levels.
  • Correlating reduced oxidative stress with decreased atherogenic risk.

Main Results:

  • Dietary Nrf2 activators were found to increase the expression of phase 2 protein genes.
  • This increase in gene expression led to a significant reduction in cellular oxidative stress.
  • Reduced oxidative stress is linked to a lower probability of atherosclerotic lesion development.

Conclusions:

  • Nrf2 activators represent a promising dietary strategy to combat oxidative stress.
  • By lowering oxidative stress, Nrf2 activators may offer a protective effect against atherosclerosis.
  • Targeting the Nrf2 pathway could be beneficial for cardiovascular health.