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Published on: June 4, 2021

Left ventricular thrombus and subsequent thromboembolism, comparison of anticoagulation, surgical removal, and

Joo Myung Lee1, Jin Joo Park, Hee Won Jung

  • 1Seoul National University Hospital, Seoul, South Korea.

Journal of Atherosclerosis and Thrombosis
|September 19, 2012
PubMed

Insights

Left ventricular (LV) thrombus increases systemic thromboembolism risk. Operative treatment showed a trend towards fewer post-treatment thromboembolic events compared to anticoagulation or antiplatelet agents.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Thrombosis Research

Background:

  • Left ventricular (LV) thrombus is a significant risk factor for systemic thromboembolism.
  • Current therapeutic strategies include anticoagulation, operative treatment, and antiplatelet agents, but their long-term comparative outcomes require further investigation.

Purpose of the Study:

  • To compare the long-term clinical outcomes of left ventricular thrombus treatments.
  • To identify independent predictors of systemic thromboembolism in patients with LV thrombus.

Main Methods:

  • A retrospective review of 62 patients diagnosed with LV thrombus between May 2003 and November 2011.
  • Patients were categorized by treatment group: anticoagulation, operative treatment, and antiplatelet agents.
  • Analysis included baseline characteristics, imaging data, thrombus outcomes, thromboembolic events, and treatment complications.

Main Results:

  • The majority of LV thrombus cases (80.6%) were of ischemic etiology.
  • Systemic thromboembolism occurred in 18 patients, with 8 events post-treatment.
  • Independent predictors of post-treatment thromboembolism included dilated cardiomyopathy, prior cerebrovascular events, female gender, and LV end-diastolic diameter.

Conclusions:

  • While the rate of post-treatment thromboembolism did not significantly differ among treatment groups, operative treatment demonstrated a trend towards lower rates.
  • Dilated cardiomyopathy, previous cerebrovascular events, female gender, and LV end-diastolic diameter are significant predictors of post-treatment thromboembolism.
Abstract

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