Related Experiment Video
Updated: May 18, 2026
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Transcatheter closure of multiple perimembranous ventricular septal defects with septal aneurysm using two
Vimalarani Devendran1, Nageswara Rao Koneti, Vimala Jesudian
1Institute of Cardiovascular Diseases, The Madras Medical Mission, 4A, Dr. J. J. Nagar, Mogappair, Chennai, 600037, India.
Insights
Transcatheter closure of perimembranous ventricular septal defects (Pm VSDs) can be challenging. A novel retrograde approach using two Amplatzer Duct Occluder II (ADO II) devices successfully treated multiple Pm VSDs in a child.
Area of Science:
- Pediatric Cardiology
- Interventional Cardiology
- Congenital Heart Disease
Background:
- Ventricular septal defect (VSD) is a common congenital heart defect in children.
- Perimembranous VSD (Pm VSD) constitutes approximately 70% of VSD cases.
- Traditional transcatheter closure of Pm VSDs with specific devices carries risks of major adverse events.
Abstract:
Ventricular septal defect (VSD) is a common congenital heart defect in children. Perimembranous VSD (Pm VSD), a defect involving the membranous septum and the adjacent portion of the muscular septum, accounts for about 70 % of cases. Transcatheter closure of Pm VSDs using the Amplatzer Pm VSD device, although successful in many patients, has been associated with major adverse events. Complete heart block, thromboembolism, and new-onset valvular regurgitations in patients undergoing VSD closure using the Pm VSD occluder have been reported [3]. Recently, a new retrograde approach for transcatheter closure of Pm VSDs using the Amplatzer Duct Occluder II (ADO II) has been described with a 90 % success rate [1]. This report describes a child who had multiple Pm VSDs with septal aneurysm undergoing successful transcatheter closure using two ADO II occluders with relative ease.
