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Chest pain in the emergency department: the case against our current practice of routine noninvasive testing
Vinay Prasad1, Michael Cheung, Adam Cifu
1Department of Medicine, Northwestern University, Chicago, IL 60611, USA. v-prasad@md.northwestern.edu
Insights
Routine noninvasive testing for resolved chest pain may not improve outcomes or reduce myocardial infarction rates. Evidence-based trials are needed to determine if any testing is superior to no further intervention for emergency department patients.
Area of Science:
- Cardiology
- Emergency Medicine
- Clinical Practice Guidelines
Background:
- Current guidelines recommend routine noninvasive testing for emergency department patients with resolved chest pain and no initial abnormalities.
- This practice aims to minimize missed myocardial infarctions and associated physician liability.
- Negative stress tests offer reassurance, while positive results indicate higher event rates and potential revascularization.
Purpose of the Study:
- To question the efficacy of current routine noninvasive testing protocols for chest pain.
- To investigate if current practices lead to unnecessary interventions in asymptomatic patients.
- To determine if routine testing improves patient outcomes or reduces myocardial infarction rates.
Main Methods:
- Review of current clinical practice and guidelines (ACC/AHA).
- Analysis of population data regarding coronary artery disease diagnosis and intervention rates.
- Proposal for randomized trials comparing routine testing versus no further intervention.
Main Results:
- Existing randomized trials in other contexts show negative results for routine stress testing.
- Population data suggest increased coronary artery disease diagnoses and interventions without decreased myocardial infarction rates.
- Current practice may lead to unnecessary procedures for noncardiac chest pain.
Conclusions:
- The effectiveness and necessity of routine noninvasive testing for resolved chest pain require further investigation.
- Randomized trials are crucial to establish an evidence-based approach and potentially alter current clinical practice.
- The current strategy may not be optimizing patient outcomes or resource allocation.
Abstract:
Current clinical practice for patients presenting to the emergency department with a resolved episode of chest pain and no electrographic or biomarker abnormalities is to conduct routine noninvasive testing, in accordance with American College of Cardiology and American Heart Association guidelines. The rationale is to further reduce the risk of missing a myocardial infarction, a major source of suits filed against emergency department physicians. Patients with negative stress test results may be reassured, with low event rates in the subsequent 30 days. Patients with positive stress test results have higher 30-day event rates, and a small fraction undergo revascularization procedures. Despite this endorsement, open questions remain. Does our current practice lead to the stenting of asymptomatic patients in the inevitable cases where the inciting pain was noncardiac? And, most importantly, does our practice improve outcomes? Randomized trials evaluating routine stress testing in other contexts have yielded negative results, despite diagnosing significant coronary artery disease. Population data suggest that our current practice may be increasing the diagnosis of coronary artery disease and the rate of intervention while failing to decrease rates of myocardial infarction. We propose that randomized trials be conducted to evaluate whether any testing is better than no further intervention. Data from such an evidence-based approach has the potential to reverse our current practice.
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