Abnormal expression of Tie1 on the valves of great saphenous varicose vein

Related Experiment Video

Updated: May 18, 2026

Isolation of Murine Valve Endothelial Cells
09:34

Isolation of Murine Valve Endothelial Cells

Published on: August 21, 2014

Xin Wang1, Rong Zhao, Changjian Liu

  • 1Department of Vascular Surgery, Affiliated Drum Tower Hospital, Medical College of Nanjing University.

Phlebology
|September 19, 2012
PubMed

Insights

Decreased Tie1 expression in great saphenous vein valves is linked to lower extremity varicose veins. This finding suggests Tie1

Area of Science:

  • Vascular Biology
  • Molecular Medicine

Background:

  • Varicose veins are a common vascular disorder.
  • The role of specific molecular markers in varicose vein pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the expression of Tie1 in great saphenous vein valves.
  • To explore the association between Tie1 expression and the pathogenesis of lower extremity varicose veins.

Main Methods:

  • Immunohistochemistry was used to assess CD31 and Tie1 expression in venous valves from patients with varicose veins and controls.
  • Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were employed to evaluate Tie1 mRNA and protein levels.

Main Results:

  • Varicose vein valves showed significantly weaker Tie1 expression compared to normal valves.
  • CD31 expression was also altered in varicose vein valves.
  • Tie1 mRNA levels were markedly reduced in varicose veins.

Conclusions:

  • Reduced Tie1 expression is implicated in the pathogenesis of primary lower extremity varicose veins.
  • Tie1 may serve as a potential biomarker for varicose vein development.
Abstract

Keywords:
Tie1 genevaricose veinvenous valve

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