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Updated: May 18, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA
David M Chenoweth1, Jordan L Meier, Peter B Dervan
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, 91125, USA.
Abstract:
Groove specificity: pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.
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