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Related Experiment Video

Updated: May 18, 2026

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Molecular catch and release: controlled delivery using optical trapping with light-responsive liposomes.

Sarah J Leung1, Marek Romanowski

  • 1Department of Biomedical Engineering, University of Arizona, Tucson, 85721, USA.

Advanced Materials (Deerfield Beach, Fla.)
|September 19, 2012
PubMed
Summary

Researchers precisely deliver molecular payloads using gold-coated liposomes guided by optical traps. This nanotechnology allows controlled cargo release for targeted cellular delivery and analysis within biological environments.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Cell Biology

Background:

  • Liposomes are widely used for drug and molecular delivery.
  • Precise control over liposome movement and cargo release remains a challenge in targeted therapies.

Purpose of the Study:

  • To develop a method for precise, controlled delivery of molecular payloads using gold-coated liposomes.
  • To demonstrate independent control over liposome movement and payload release.

Main Methods:

  • Utilizing optical traps to maneuver gold-coated liposomes.
  • Employing a pulsed trapping beam to control movement and trigger payload release.
  • Performing in vitro delivery to selected cells.

Main Results:

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Last Updated: May 18, 2026

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
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Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

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  • Gold-coated liposomes were successfully maneuvered using optical traps.
  • Independent control of liposome movement and cargo release was achieved.
  • In vitro delivery of encapsulated molecular cargo to a selected cell was demonstrated.

    • Conclusions:

    • Optical trapping of gold-coated liposomes offers a precise method for targeted molecular delivery.
    • This technology enables controlled payload release for cellular interrogation.
    • Potential applications include studying individual cells within their native biological microenvironments.